[Download] ~ Hormetic Triggers for Intervention in Aging, Disease and Trauma (Report) * by American Journal of Pharmacology and Toxicology ~ eBook PDF Kindle ePub Free
eBook details
- Title: Hormetic Triggers for Intervention in Aging, Disease and Trauma (Report)
- Author : American Journal of Pharmacology and Toxicology
- Release Date : January 01, 2008
- Genre: Health & Fitness,Books,Health, Mind & Body,
- Pages : * pages
- Size : 235 KB
Description
INTRODUCTION Hans Seyle emphasized that we must be guided by the principle to learn to imitate-and if necessary to correct and complement-the body's own molecular mechanisms used to combat the stress factor in disease [1]. Metabolic pathways conserved throughout evolution are likely biologically important survival strategies. There is increasing evidence that survival mechanisms found in primitive organisms may be conserved as latent pathways in higher organisms which could be activated with the appropriate molecular triggers to promote physiological hormesis. The identification and use of molecular mimics of stress to access molecular pathways for survival represents a major strategy for disease prevention, recovery, longevity and survival in man. Candidate pharmaceutical agents which imitate the physical and environmental SOS signals to activate complete or partial molecular cascades common to heat, radiation, diet restriction, cell immunity and trauma have been identified and are reviewed below for intervention in aging, disease and trauma. In concert with the integration of the concepts of adaptive response and preconditioning stress within a hormetic dose response framework, the recommendations for common terminology are employed to facilitate better understanding and communications between different disciplines and illumination of common molecular survival tools [2]. Hormesis is an adaptive response characterized by biphasic dose response patterns that at low doses enhances the ability of the cells or organism to withstand more severe stress or compensatory biological processes following an initial disruption of homeostasis. The hormetic response is the adaptive stress response [3]. Examples of the general pattern of conserved hormetic pathways include those involving heat-shock proteins, antioxidant systems and anti-apoptotic pathways [4]. Here, the review focuses on hormetic mimetics of heat, radiation, caloric restriction, immunoregulators and hibernation for their potential use in anti-aging, disease and trauma. The review focuses on elucidating common pathways that delay age-associated diseases and promote longevity using mimetics of known hormetic signals (Table 1, 2).